simtte - Simulate Time-to-Event Data from PK/PD and Bespoke ODE Models

Simulates time-to-event (survival) datasets for clinical trial design and analysis, including datasets driven by a joint pharmacokinetic/pharmacodynamic (PK/PD) model solved via the 'mrgsolve' backend. Event times can be located directly during ODE integration ('in-solver' event detection) using a library of built-in PK/PD hazard models or a user-supplied 'mrgsolve' model converted for this purpose, or generated by inverse transform sampling from a closed-form Weibull or flexible M-spline baseline hazard, or from any externally simulated survival trajectory. See Bender et al. (2005) <doi:10.1002/sim.2059> for the inverse transform sampling methodology and Royston and Parmar (2002) <doi:10.1002/sim.1203> for flexible parametric survival models.