Package: simtte
Title: Simulate Time-to-Event Data from PK/PD and Bespoke ODE Models
Version: 1.1.0
Language: en-US
Authors@R: person("Carlos", "Traynor", email = "carlos.traynor.qcp@gmail.com",
    role = c("aut", "cre"))
Description: Simulates time-to-event (survival) datasets for clinical
        trial design and analysis, including datasets driven by a joint
        pharmacokinetic/pharmacodynamic (PK/PD) model solved via the
        'mrgsolve' backend. Event times can be located directly during
        ODE integration ('in-solver' event detection) using a library
        of built-in PK/PD hazard models or a user-supplied 'mrgsolve'
        model converted for this purpose, or generated by inverse
        transform sampling from a closed-form Weibull or flexible
        M-spline baseline hazard, or from any externally simulated
        survival trajectory. See Bender et al. (2005)
        <doi:10.1002/sim.2059> for the inverse transform sampling
        methodology and Royston and Parmar (2002)
        <doi:10.1002/sim.1203> for flexible parametric survival models.
License: GPL (>= 2)
Encoding: UTF-8
LazyData: true
Depends: R (>= 4.0.0)
Imports: dplyr, magrittr, methods, mrgsolve, tools
Suggests: callr, testthat (>= 3.0.0), knitr, pkgload, rmarkdown,
        splines2, survival
VignetteBuilder: knitr
URL: https://github.com/csetraynor/simtte
BugReports: https://github.com/csetraynor/simtte/issues
Config/testthat/edition: 3
Config/roxygen2/version: 8.0.0
RoxygenNote: 8.0.0
Repository: https://csetraynor.r-universe.dev
Date/Publication: 2026-10-30 22:43:53 UTC
RemoteUrl: https://github.com/csetraynor/simtte
RemoteRef: HEAD
RemoteSha: 652c6ee92553c617d5b2d5edbd97785a258f7072
NeedsCompilation: no
Packaged: 2026-10-31 01:18:54 UTC; root
Author: Carlos Traynor [aut, cre]
Maintainer: Carlos Traynor <carlos.traynor.qcp@gmail.com>